Modulation by Co (II) Ion of Optical Activities of L/D‐glutathione (GSH)‐modified Chiral Copper Nanoclusters for Sensitive Adenosine Triphosphate Detection

纳米团簇 谷胱甘肽 化学 三磷酸腺苷 离子 无机化学 组合化学 生物化学 有机化学
作者
Qi Ding,Weimin Yang,Xianglong Xing,Hengwei Lin,Chuanlai Xu,Liguang Xu,Si Li
出处
期刊:Angewandte Chemie [Wiley]
标识
DOI:10.1002/ange.202401032
摘要

Chiral nanoscale enantiomers exhibit different biological effects in living systems. However, their chirality effect on the detection sensitivity for chiral biological targets still needs to be explored. Here, we discovered that Co2+ can modulate the luminescence performance of L/D‐glutathione (GSH)‐modified copper nanoclusters (L/D‐Cu NCs) and induce strong chiroptical activities as the asymmetric factor was enhanced 223‐fold with their distribution regulating from the ultraviolet to visible region. One Co2+ coordinated with two GSH molecules that modified on the surface of Cu NCs in the way of CoN2O2. On this basis, dual‐modal chiral and luminescent signals of Co2+ coordinated L/D‐Cu NCs (L/D‐Co‐Cu NCs) were used to detect the chiral adenosine triphosphate (ATP) based on the competitive interaction between surficial GSH and ATP molecules with Co2+. The limits of detection of ATP obtained with fluorescence and circular dichroism intensity were 9.15 μM and 15.75 nM for L‐Co‐Cu NCs, and 5.35 μM and 4.69 nM for D‐Co‐Cu NCs. This demonstrated that selecting suitable chiral configurations of nanoprobes effectively enhances detection sensitivity. This study presents not only a novel method to modulate and enhance the chiroptical activity of nanomaterials but also a unique perspective of chirality effects on the detection performances for bio‐targets.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ct551144发布了新的文献求助10
1秒前
蔡蔡完成签到,获得积分10
1秒前
路路有为完成签到 ,获得积分10
3秒前
4秒前
windyhill完成签到,获得积分10
4秒前
FashionBoy应助科研通管家采纳,获得10
8秒前
搜集达人应助科研通管家采纳,获得10
8秒前
科研通AI2S应助科研通管家采纳,获得10
8秒前
华仔应助科研通管家采纳,获得10
9秒前
情怀应助科研通管家采纳,获得10
9秒前
9秒前
Orange应助科研通管家采纳,获得10
9秒前
9秒前
9秒前
NexusExplorer应助彩色的芷容采纳,获得10
9秒前
10秒前
柒_l发布了新的文献求助10
10秒前
马大翔应助yoo采纳,获得10
11秒前
12秒前
C洛7完成签到,获得积分10
13秒前
林和应助文件撤销了驳回
15秒前
shirley完成签到,获得积分10
15秒前
15秒前
Akim应助aa采纳,获得10
15秒前
刘璇1发布了新的文献求助10
15秒前
16秒前
大罗完成签到,获得积分10
16秒前
tao完成签到 ,获得积分10
21秒前
22秒前
24秒前
囚徒发布了新的文献求助10
25秒前
勤恳的不二完成签到,获得积分10
25秒前
冬瓜熊完成签到,获得积分10
27秒前
aa发布了新的文献求助10
29秒前
华仔应助囚徒采纳,获得10
32秒前
Yuksn完成签到,获得积分10
33秒前
Cool完成签到,获得积分10
35秒前
38秒前
wickedzz完成签到,获得积分10
39秒前
40秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3061897
求助须知:如何正确求助?哪些是违规求助? 2716949
关于积分的说明 7452165
捐赠科研通 2362913
什么是DOI,文献DOI怎么找? 1252481
科研通“疑难数据库(出版商)”最低求助积分说明 608036
版权声明 596550