透明质酸
化学
活性氧
氧化应激
生物相容性
氧化磷酸化
内吞作用
泡沫电池
脂蛋白
抗氧化剂
生物化学
胆固醇
受体
医学
有机化学
解剖
作者
Sheng Wang,Jingwen Zhang,Wei Li,Dali Chen,Jiasheng Tu,Chunmeng Sun,Yunai Du
标识
DOI:10.1016/j.carbpol.2022.119940
摘要
Oxidative stress is a distinguishing feature in atherosclerosis disease. Reactive oxygen species (ROS) can increase the oxidized low density lipoprotein (ox-LDL) and oxidative damage to macrophages in the plaque. Although antioxidant agents such as N-acetylcysteine are used to treat atherosclerosis, but provide a poor clinical benefit to the majority of patients with atherosclerosis. Here we have designed hyaluronic acid-guided assemblies of ceria nanozymes (HA-CeO2 NPs) as novel plaque-targeting ROS scavengers. The introduction of hyaluronic acid not only provide the stability and biocompatibility, but also surprisingly enhance SOD-mimic activities of ceria nanozymes compared to bare CeO2 precipitates, dextran or poly-aspartic acid coated ceria nanozymes. Interestingly, we find HA-CeO2 NPs not only actively target plaque-associated macrophages in atherosclerosis to remove superfluous ROS and protect macrophages from ROS-caused damages, but also effectively inhibit endocytosis of ox-LDL by activated macrophages. We believe HA-CeO2 nanozymes can serve as a simple and promising platform for anti-atherosclerotic therapy.
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