Association between the dietary inflammatory index (DII) and telomere length and C‐reactive protein from the National Health and Nutrition Examination Survey‐1999–2002

全国健康与营养检查调查 四分位数 医学 C反应蛋白 端粒 置信区间 内科学 卡路里 炎症 生物标志物 免疫学 环境卫生 生物 人口 DNA 生物化学 遗传学
作者
Nitin Shivappa,Michael D. Wirth,Thomas G. Hurley,James R. Hébert
出处
期刊:Molecular Nutrition & Food Research [Wiley]
卷期号:61 (4) 被引量:145
标识
DOI:10.1002/mnfr.201600630
摘要

Leukocyte telomere length (LTL) is an important biomarker of aging. This study examined whether inflammatory potential of diet, as measured by the Dietary Inflammatory IndexTM (DII) has an impact on telomere shortening in the National Health and Nutrition Examination Survey (NHANES). We also carried out validation of the DII with C-reactive protein (CRP).Data came from NHANES 1999-2002. LTL and CRP were assayed from leukocyte DNA and serum specimens, respectively. The DII was calculated from food intakes assessed using 24-h dietary recalls and expressed per 1000 calories consumed. Associations were examined using survey-based multivariable linear regression for log-transformed LTL. After multivariable adjustment, higher DII scores (i.e. relatively more pro inflammatory) were associated with shorter LTL both when used as continuous (b = -0.003; 95% confidence interval [CI] = -0.005, -0.0002) and as quartiles (bDIIquartile4vs1 = -0.013; 95% CI = -0.025, -0.001; Ptrend = .03). In this same sample the DII also was associated with CRP ≥3 mg/L (ORDIIcontinuous = 1.10; 95% CI = 1.06, 1.16).In these NHANES data there was an association between DII and LTL. This study also provided a successful construct validation of the DII using CRP in a nationally representative sample. These results are consistent with the hypothesis that diet-associated inflammation determines LTL.
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