Randomized sham-controlled pilot trial of weekly electro-acupuncture for the prevention of taxane-induced peripheral neuropathy in women with early stage breast cancer

医学 化疗所致周围神经病变 紫杉烷 乳腺癌 周围神经病变 随机对照试验 内科学 简短疼痛清单 化疗 针灸科 癌症 物理疗法 慢性疼痛 内分泌学 糖尿病 替代医学 病理
作者
Heather Greenlee,Katherine D. Crew,Jillian L. Capodice,Danielle Awad,Donna Buono,Zaixing Shi,Anne Jeffres,Sharon Wyse,Wendy Whitman,Meghna S. Trivedi,Kevin Kalinsky,Dawn L. Hershman
出处
期刊:Breast Cancer Research and Treatment [Springer Nature]
卷期号:156 (3): 453-464 被引量:89
标识
DOI:10.1007/s10549-016-3759-2
摘要

To investigate the effect of electro-acupuncture (EA) as a non-pharmacological intervention to prevent or reduce chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients undergoing chemotherapy of taxane. Women with stage I-III breast cancer scheduled to receive taxane therapy were randomized to receive a standardized protocol of 12 true or sham EA (SEA) weekly treatments concurrent with taxane treatment. Subjects completed the Brief Pain Inventory-Short Form (BPI-SF), Functional Assessment of Cancer Therapy-Taxane neurotoxicity subscale (FACT-NTX), and other assessments at baseline and weeks 6, 12, and 16. A total of 180 subjects were screened, 63 enrolled and 48 completed week 16 assessments. Mean age was 50 with 25 % white, 25 % black, and 43 % Hispanic; 52 % had no prior chemotherapy. At week 12, both groups reported an increase in mean BPI-SF worst pain score, but no mean differences were found between groups (SEA 2.8 vs. EA 2.6, P = .86). By week 16, the SEA group returned to baseline, while the EA group continued to worsen (SEA 1.7 vs. EA 3.4, P = .03). The increase in BPI-SF worst pain score was 1.62 points higher in the EA group than in the SEA group at week 16 (P = .04). In a randomized, sham-controlled trial of EA for prevention of taxane-induced CIPN, there were no differences in pain or neuropathy between groups at week 12. Of concern, subjects on EA had a slower recovery than SEA subjects. Future studies should focus on EA for treatment as opposed to prevention of CIPN.
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