鞘脂
神经酰胺
Wnt信号通路
鞘氨醇
结直肠癌
生物
脂质信号
信号转导
1-磷酸鞘氨醇
癌症
细胞生物学
酶
生物化学
遗传学
受体
细胞凋亡
作者
Mönica García‐Barros,Nicolas Coant,Jean‐Philip Truman,Ashley J. Snider,Yusuf A. Hannun
标识
DOI:10.1016/j.bbalip.2013.09.007
摘要
Colorectal cancer is one of the major causes of death in the western world. Despite increasing knowledge of the molecular signaling pathways implicated in colon cancer, therapeutic outcomes are still only moderately successful. Sphingolipids, a family of N-acyl linked lipids, have not only structural functions but are also implicated in important biological functions. Ceramide, sphingosine and sphingosine-1-phosphate are the most important bioactive lipids, and they regulate several key cellular functions. Accumulating evidence suggests that many cancers present alterations in sphingolipids and their metabolizing enzymes. The aim of this review is to discuss the emerging roles of sphingolipids, both endogenous and dietary, in colon cancer and the interaction of sphingolipids with WNT/β-catenin pathway, one of the most important signaling cascades that regulate development and homeostasis in intestine. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
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