镧系元素
明胶
荧光
发光
金属有机骨架
荧光寿命成像显微镜
自愈水凝胶
亚历山福禄
显像剂
材料科学
化学
纳米技术
光电子学
高分子化学
光学
物理化学
吸附
有机化学
离子
物理
生物技术
体内
生物
作者
Haoran Ji,Xiao‐Feng Wang,Pei Wang,Yan Gong,Yun Wang,Chang Liu,Guangyu Ji,Xiansong Wang,Mingsong Wang
标识
DOI:10.1186/s12951-022-01263-6
摘要
The localization of invisible and impalpable small pulmonary nodules has become an important concern during surgery, since current widely used techniques for localization have a number of limitations, such as invasive features of hookwires and microcoils, and rapid diffusion after injection of indocyanine green (ICG). Lanthanide-based metal-organic frameworks (MOFs) have been proven as potential fluorescent agents because of their prominent luminescent characteristics, including large Stokes shifts, high quantum yields, long decay lifetimes, and undisturbed emissive energies. In addition, lanthanides, such as Eu, can efficiently absorb X-rays for CT imaging. In this study, we synthesized Eu-UiO-67-bpy (UiO = University of Oslo, bpy = 2,2'-bipyridyl) as a fluorescent dye with a gelatin-methacryloyl (GelMA) hydrogel as a liquid carrier. The prepared complex exhibits constant fluorescence emission owing to the luminescent characteristics of Eu and the stable structure of UiO-67-bpy with restricted fluorescence diffusion attributed to the photocured GelMA. Furthermore, the hydrogel provides stiffness to make the injection site tactile and improve the accuracy of localization and excision. Finally, our complex enables fluorescence-CT dual-modal imaging of the localization site.
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