材料科学
杰纳斯
生物膜
二氧化钛
纳米颗粒
纳米技术
一氧化氮
氧化物
氧化钛
化学工程
复合材料
冶金
细菌
有机化学
化学
工程类
生物
遗传学
作者
Weichen Zhao,Qihang Ding,Bingshuai Zhou,Jia Liu,Yujia Shi,Chengyu Liu,Chunyan Li,Biao Dong,Manlin Qi,Jong Seung Kim,Lin Wang
标识
DOI:10.1002/adfm.202407626
摘要
Abstract Sonodynamic therapy (SDT) is promising for combating deep‐seated infectious diseases by generating substantial reactive oxygen species (ROS) through the profound tissue penetration capabilities of ultrasound. However, the compact protective structures of bacterial biofilms present a formidable challenge, impeding ROS efficacy. Given that ROS have a limited diffusion range and current sonosensitizers struggle to infiltrate biofilms, complete eradication of pathogenic bacteria often remains unachieved. In this study, mesoporous titanium dioxide (TiO 2 ) nanoparticles are engineered asymmetrically coated with a thin layer of Ag and loaded with L‐arginine (LA) to construct ultrasound‐propelled nanomotors. These Ag‐TiO 2 ‐LA Janus nanoparticles demonstrate robust self‐propulsion upon ultrasonic activation, allowing for deeper penetration into biofilm matrices and enhancing localized biofilm disruption through improved SDT outcomes. Additionally, the incorporation of Ag not only broadens TiO 2 ’s absorption spectrum but also confers photothermal capabilities upon NIR laser excitation at 808 nm. The Ag‐TiO 2 ‐LA nanomotor amalgamates TiO 2 ’s sonodynamic potential with Ag's photothermal properties, forging a versatile antimicrobial agent capable of efficient biofilm penetration and a synergistic antibacterial effect when subjected to dual NIR and ultrasound stimuli. This innovative, singularly‐structured nanoparticle stands out as an effective combatant against bacterial biofilms and accelerates the healing process of infected wounds, showcasing potential for multifaceted clinical applications.
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