化学
表面改性
过渡金属
反应性(心理学)
氢原子
激进的
金属
分子
光化学
组合化学
有机化学
催化作用
物理化学
医学
烷基
替代医学
病理
作者
Xinghua Wang,J. P. He,Yanan Wang,Zhenyan Zhao,Kui Jiang,Wei Ma,Tao Zhang,Shiqi Jia,Kangbao Zhong,Linbin Niu,Yu Lan
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2024-08-08
卷期号:124 (17): 10192-10280
标识
DOI:10.1021/acs.chemrev.4c00188
摘要
Radical C–H functionalization represents a useful means of streamlining synthetic routes by avoiding substrate preactivation and allowing access to target molecules in fewer steps. The first-row transition metals (Ti, V, Cr, Mn, Fe, Co, Ni, and Cu) are Earth-abundant and can be employed to regulate radical C–H functionalization. The use of such metals is desirable because of the diverse interaction modes between first-row transition metal complexes and radical species including radical addition to the metal center, radical addition to the ligand of metal complexes, radical substitution of the metal complexes, single-electron transfer between radicals and metal complexes, hydrogen atom transfer between radicals and metal complexes, and noncovalent interaction between the radicals and metal complexes. Such interactions could improve the reactivity, diversity, and selectivity of radical transformations to allow for more challenging radical C–H functionalization reactions. This review examines the achievements in this promising area over the past decade, with a focus on the state-of-the-art while also discussing existing limitations and the enormous potential of high-value radical C–H functionalization regulated by these metals. The aim is to provide the reader with a detailed account of the strategies and mechanisms associated with such functionalization.
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