化学
神经活性类固醇
别孕甾酮
雄甾烷
抗焦虑药
类固醇
雄烯二醇
睾酮(贴片)
孕酮
药理学
受体
立体化学
内分泌学
γ-氨基丁酸受体
生物化学
激素
脱氢表雄酮
雄激素
医学
作者
Tatsuya Higashi,Asuka Tanaka,Shiho Tsubura,Shoichi Nishimoto‐Kusunose
摘要
5α-Androstane-3α,17β-diol (3α,5α-Adiol) is a testosterone-derived neurosteroid and has anxiolytic and analgesic effects via γ-aminobutyric acid type A receptors as with the progesterone-derived neurosteroid, allopregnanolone (AP). Although the psychotropic drug-evoked changes in the brain AP concentration have been intensively studied, those in the brain 3α,5α-Adiol concentration remain poorly understood. One of the causes for this is the limited availability of a validated method for quantifying the brain 3α,5α-Adiol with a sufficient sensitivity and specificity, which is described in this study.
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