Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults

医学 脂肪肝 内科学 全国健康与营养检查调查 骨关节炎 优势比 逻辑回归 肥胖 代谢综合征 疾病 横断面研究 胃肠病学 病理 替代医学 人口 环境卫生
作者
Lu Yu,Jianyu Zhang,Hejun Li,Ting Li
出处
期刊:Arthritis Research & Therapy [BioMed Central]
卷期号:26 (1) 被引量:1
标识
DOI:10.1186/s13075-024-03272-2
摘要

Abstract Background The association between non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA) has not been well elucidated. The aim of the present study was to investigate the association between NAFLD and OA in the US adults. Methods A cross-sectional study was performed on participants in the 2017–2018 National Health and Nutrition Examination Survey (NHANES) cycle. NAFLD was defined by the vibration-controlled transient elastography. The diagnosis of OA was based on self-reported data. Weighted multiple logistic regression models and stratified analyses were performed to explore the relationship and verify the stability of the conclusions. Sensitivity analysis using multiple imputation for missing data and propensity score matching (PSM) were performed. Results In total, 2622 participants [Male: 1260 (47.8%)] were included in this study with a mean age of 48.1 years old (95% CI, 46.6–49.6 years old), containing 317 (12.8%) OA patients and 1140 NAFLD patients (41.5%). A logistic regression indicated a significant association between NAFLD and OA without adjustment [odds ratio (OR) = 2.05; 95% CI, 1.52–2.78]. The association remained stable after adjustment for covariates (OR = 1.72; 95% CI, 1.26–2.34). Sensitivity analysis of missing data with multiple interpolation and PSM found similar results. A significant and consistent association of NAFLD with OA was still observed in each subgroup stratified by age and metabolic syndrome (MetS). Stratified by sex, obesity, and sensitivity c-reactive protein (hs-CRP) category, a statistically significant association was only shown in females, those without obesity, and those without hyper hs-CRP. The results illustrated that the relationship between NAFLD and OA was stable in all subgroups and had no interaction. Conclusions NAFLD was positively correlated with OA. Given the current pandemic of NAFLD and OA, clinicians should screen for NAFLD in arthritis patients and intervene early.
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