超声
泊洛沙姆
Zeta电位
生物利用度
肺表面活性物质
纳米载体
小檗碱
哈卡特
化学
粒径
溶解度
泊洛沙姆407
析因实验
油酸
色谱法
溶解
硬脂酸
活性成分
毒品携带者
活力测定
材料科学
药物输送
药理学
纳米颗粒
纳米技术
有机化学
体外
生物化学
聚合物
医学
统计
数学
物理化学
共聚物
作者
Van Hong Nguyen,Mai Chau Ngoc Nguyen,Huyen Thi Trang Nguyen
出处
期刊:Advances in Natural Sciences: Nanoscience and Nanotechnology
[IOP Publishing]
日期:2024-12-30
卷期号:16 (1): 015002-015002
标识
DOI:10.1088/2043-6262/ada002
摘要
Abstract Berberine (BBR), a natural bioactive ingredient from Eastern nations, has low solubility and permeability that limits its applications. Hence, berberine nanostructured lipid carriers (BBR-NLCs) were fabricated to improve the drug therapeutic effectiveness. Glycerol monostearate, stearic acid and oleic acid were chosen for lipid base whereas Pluronic F127, Span 80, and Transcutol-P were used as the surfactant and co-surfactant. BBR-NLCs had an average particle size of 82 nm, zeta potential of −32 mV, and narrow size distribution (PDI approximately 0.2), prepared with probe ultrasonication at 490 W in 15 min. In addition, BBR-NLCs prepared at optimized conditions showed around 92% of encapsulation efficiency with drug loading over 5.5%. NLCs presented sustained released through mouse skin, dialysis membrane in Franz cell model, and oral dissolution test, compared with free drug over 24 h. Moreover, blank NLCs even increased the cell viability of HaCaT and HEK293T cells at lower concentrations. NLCs significantly enabled higher interactive BBR quantity with investigated cells. Therefore, BBR-NLCs could be considered as a potential nanocarrier for improved bioavailability of this therapeutic agent.
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