药物发现
药品
候选药物
鉴定(生物学)
计算生物学
药物开发
药理学
医学
生物信息学
计算机科学
生物
植物
作者
Fredrik Bergström,Bo Lindmark
标识
DOI:10.1016/j.drudis.2019.03.026
摘要
The eventual candidate drug (CD) is often already synthesized during early drug discovery but not nominated until much later. To facilitate the rapid identification of a potential CD, a thoroughly worked-out CD target profile (CDTP) with criteria acceptable for the disease target product profile (TPP) is required at the start of lead generation (LG). In addition to driving the compound property optimization, the preclinical project team has to understand the ultimate goal to be able to rapidly identify and progress a potential CD. A screening cascade with meaningful and well-balanced progression criteria based on the CDTP is required to rapidly filter out unwanted compounds and to progress a potential CD through the cascade to candidate selection.
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