催化作用
持续性
化学
稀缺
纳米技术
生化工程
贵金属
母材
可持续发展
环境科学
材料科学
工程类
有机化学
政治学
冶金
经济
生物
微观经济学
法学
焊接
生态学
作者
Aleksandra Piontek,Elwira Bisz,Michal Szostak
标识
DOI:10.1002/anie.201800364
摘要
The scarcity of precious metals has led to the development of sustainable strategies for metal-catalyzed cross-coupling reactions. The establishment of new catalytic methods using iron is attractive owing to the low cost, abundance, ready availability, and very low toxicity of iron. In the last few years, sustainable methods for iron-catalyzed cross-couplings have entered the critical area of pharmaceutical research. Most notably, iron is one of the very few metals that have been successfully field-tested as highly effective base-metal catalysts in practical, kilogram-scale industrial cross-couplings. In this Minireview, we critically discuss the strategic benefits of using iron catalysts as green and sustainable alternatives to precious metals in cross-coupling applications for the synthesis of pharmaceuticals. The Minireview provides an essential introduction to the fundamental aspects of practical iron catalysis, highlights areas for improvement, and identifies new fields to be explored.
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