Study of EEG microstates in Parkinson’s disease: a potential biomarker?

库尼乌斯 楔前 地方政府 痴呆 静息状态功能磁共振成像 神经科学 脑电图 心理学 帕金森病 默认模式网络 颞叶 顶叶 听力学 医学 内科学 疾病 癫痫 认知
作者
Anita Pal,Madhuri Behari,Vinay Goyal,Ratna Sharma
出处
期刊:Cognitive Neurodynamics [Springer Nature]
卷期号:15 (3): 463-471 被引量:28
标识
DOI:10.1007/s11571-020-09643-0
摘要

The spontaneous activity of the brain is dynamic even at rest and the deviation from this normal pattern of dynamics can lead to different pathological states. EEG microstate analysis of resting-state neuronal activity in Parkinson's disease (PD) could provide insight into altered brain dynamics of patients exhibiting dementia. Resting-state EEG microstate maps were derived from 128 channel EEG data in 20 PD without dementia (PDND), 18 PD with dementia (PDD) and 20 Healthy controls (CON) using Cartool and sLORETA softwares. Microstate map parameters including global explained variance, mean duration, frequency of occurrence (TF) and time coverage were compared statistically among the groups. Eight maps that explained 72% of the topographic variance were identified and only three maps differed significantly across the groups. TF of Map1 was lower in both PDND and PDD (p < 0.001) and that of Map3 (p = 0.02) in PDND compared to control. Cortical sources showed higher activation in precuneus, cuneus and superior parietal lobe (Threshold: Log-F = 1.74, p < 0.05) with maximum activity in the precuneus region (MNI co-ordinates: - 25, - 75, - 40; Log-F = 1.9) in PDND compared to control only for Map1. Lower TF of Map1 (prototypical microstate D) may potentially serve as a biomarker for PD with or without dementia whereas higher activation of precuneus, cuneus and superior parietal lobe at resting-state could favour signal processing, lack of which could be associated with dementia in Parkinson's disorder.
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