分流器
动脉瘤
血流动力学
血栓形成
生物信息学
支架
机制(生物学)
心脏病学
医学
放射科
生物
内科学
物理
生物化学
量子力学
基因
作者
Krishnan Ravindran,Amanda M. Casabella,Juan R. Cebral,Waleed Brinjikji,David F. Kallmes,R Kadirvel
出处
期刊:Neurosurgery
[Lippincott Williams & Wilkins]
日期:2019-12-16
卷期号:86 (Supplement_1): S13-S19
被引量:69
标识
DOI:10.1093/neuros/nyz324
摘要
Abstract Flow diverters have drastically changed the landscape of intracranial aneurysm treatment and are now considered first-line therapy for select lesions. Their mechanism of action relies on intrinsic alteration in hemodynamic parameters, both at the parent artery and within the aneurysm sac. Moreover, the device struts act as a nidus for endothelial cell growth across the aneurysm neck ultimately leading to aneurysm exclusion from the circulation. In silico computational analyses and investigations in preclinical animal models have provided valuable insights into the underlying biological basis for flow diverter therapy. Here, we review the present understanding pertaining to flow diverter biology and mechanisms of action, focusing on stent design, induction of intra-aneurysmal thrombosis, endothelialization, and alterations in hemodynamics.
科研通智能强力驱动
Strongly Powered by AbleSci AI