肌成纤维细胞
间充质干细胞
生物
纤维化
骨髓
肺
病理
肺纤维化
干细胞移植修复关节软骨
干细胞
癌症研究
细胞生物学
免疫学
细胞分化
成体干细胞
医学
内科学
遗传学
基因
作者
Elie El Agha,Rafael Kramann,Rebekka K. Schneider,Xiaokun Li,Werner Seeger,Benjamin D. Humphreys,Savério Bellusci
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2017-08-01
卷期号:21 (2): 166-177
被引量:366
标识
DOI:10.1016/j.stem.2017.07.011
摘要
Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow.
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