医学
细胞因子
免疫系统
免疫疗法
癌症
多效性
炎症
肿瘤微环境
癌症免疫疗法
免疫学
生物
内科学
表型
生物化学
基因
作者
Kathrine S Rallis,Amber Elyse Corrigan,Hashim Dadah,Justas Stanislovas,Parisa Zamani,Shania Makker,Bernadett Szabados,Michail Sideris
出处
期刊:Future Oncology
[Future Medicine]
日期:2022-09-01
卷期号:18 (29): 3349-3365
被引量:12
标识
DOI:10.2217/fon-2022-0063
摘要
Cytokines are soluble proteins that mediate intercellular signaling regulating immune and inflammatory responses. Cytokine modulation represents a promising cancer immunotherapy approach for immune-mediated tumor regression. However, redundancy in cytokine signaling and cytokines' pleiotropy, narrow therapeutic window, systemic toxicity, short half-life and limited efficacy represent outstanding challenges for cytokine-based cancer immunotherapies. Recently, there has been interest in the paradoxical role of IL-10 in cancer, its controversial prognostic utility and novel strategies to enhance its therapeutic profile. Here, the authors review the literature surrounding the role of IL-10 within the tumor microenvironment, its prognostic correlates to cancer patient outcomes and its pro- and antitumor effects, and they assess the legitimacy of potential therapeutic strategies harnessing IL-10 by outlining the notable preclinical and clinical evidence to date.
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