Comparison of Complication Rates Between Subpectoral Vs Prepectoral Techniques in Prosthetic Breast Reconstruction

Abstract Background The location of tissue expanders in implant-based breast reconstruction remains controversial, due to variation in surgical techniques and devices. Objectives This study aims to provide a comprehensive assessment of early and late complication rates between prepectoral and subpectoral placement of tissue expanders. Methods A retrospective cohort study was conducted of all adult female patients who had two-staged implant-based breast reconstruction from 2013 to 2019 in our institution. Early complication was defined as complications that occurred within 30 days after surgery. Time-to-event analyses were performed and Cox proportional hazard models were used to adjust for confounders. Results 854 patients were included with 76% of patients underwent a subpectoral tissue expander placement. After the first stage procedure, the early complication rate was 34%, and the late complication rate was 36.4%. After the second stage procedure, the early complication rate was 16.3%, and the late complication rate was 16.1%. Location of the tissue expander did not predict either overall early or late complication rates, regardless of the stages of reconstruction, after adjusting for confounders. Tissue expanders placed in prepectoral plane were associated with a higher hazard ratio (HR) for developing early and late infection after the first stage of reconstruction (HR 2.1, HR 2.4, respectively) as well as late infection after the second stage of reconstruction (HR 5.3, all p<0.05). Conclusions Location of tissue expanders did not predict risk of complication. However, the prepectoral group was associated with an increased risk of developing infection.