FGF21型
调节器
成纤维细胞生长因子
警觉
酒精中毒
激素
生物
神经科学
内分泌学
医学
内科学
药理学
毒物控制
生物化学
伤害预防
受体
基因
环境卫生
作者
Martin Jastroch,Susanne Keipert,Matthias H. Tschöp
标识
DOI:10.1016/j.cmet.2023.02.010
摘要
Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential. Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential. FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous systemChoi et al.Cell MetabolismMarch 07, 2023In BriefChoi et al. show that the alcohol-induced hormone FGF21 signals from liver to brain to counteract loss of consciousness and coordination caused by ethanol consumption. Pharmacologic FGF21 administration further accelerates recovery from inebriation. FGF21 exerts its sobering effect by activating the noradrenergic nervous system, which regulates arousal and alertness. Full-Text PDF Open Access
科研通智能强力驱动
Strongly Powered by AbleSci AI