水泥
骨水泥
生物活性玻璃
生物材料
材料科学
硼酸盐玻璃
股骨髁
髁突
磷酸钙骨水泥
生物医学工程
硼
化学
复合材料
外科
医学
解剖
纳米技术
有机化学
软骨
作者
Xu Cui,Wenhai Huang,Yadong Zhang,Chengcheng Huang,Zunxiong Yu,Lei Wang,Wenlong Liu,Ting Wang,Jie Zhou,Hui Wang,Nai Zhou,Deping Wang,Haobo Pan,Mohamed N. Rahaman
标识
DOI:10.1016/j.msec.2016.12.101
摘要
There is a need for synthetic biomaterials to heal bone defects using minimal invasive surgery. In the present study, an injectable cement composed of bioactive borate glass particles and a chitosan bonding solution was developed and evaluated for its capacity to heal bone defects in a rabbit femoral condyle model. The injectability and setting time of the cement in vitro decreased but the compressive strength increased (8±2MPa to 31±2MPa) as the ratio of glass particles to chitosan solution increased (from 1.0gml-1 to 2.5gml-1). Upon immersing the cement in phosphate-buffered saline, the glass particles reacted and converted to hydroxyapatite, imparting bioactivity to the cement. Osteoblastic MC3T3-E1 cells showed enhanced proliferation and alkaline phosphatase activity when incubated in media containing the soluble ionic product of the cement. The bioactive glass cement showed a better capacity to stimulate bone formation in rabbit femoral condyle defects at 12weeks postimplantation when compared to a commercial calcium sulfate cement. The injectable bioactive borate glass cement developed in this study could provide a promising biomaterial to heal bone defects by minimal invasive surgery.
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