Analysis of hypertrophy-related factors in 82 adult patients with hypertrophic port-wine stains

Objective To analyze clinical features of and hypertrophy-related factors in patients with hypertrophic port-wine stains (PWS). Methods Patients with PWS were enrolled into this study from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University between January 2010 and August 2014. Clinical features of hypertrophic PWS were investigated. The factors related to hypertrophy in PWS were analyzed by univariate and multivariate unconditional logistic regression analyses. Results A total of 262 patients with PWS were enrolled, 82 (30 males and 52 females) of whom had hypertrophic PWS with a median age of 32.5 years (range, 18-54 years). Among the 82 patients, 66 (80.48%) had plaque-like hypertrophic PWS, 9 (10.98%) had papular or nodular type, and 7 (8.54%) had mixed type; 56.10% (46/82) were aged ≥ 30 years, 41.46% (34/82) varied from 11 to 30 cm2 in lesional area, and 85.36% (70/82) showed purple lesions. There was a significant difference between patients with hypertrophic PWS and those with flat PWS in the distribution of age, lesional area and color (χ2=25.559, 10.580, 90.630, respectively, all P 0.05). Multivariate unconditional logistic regression analysis revealed that an age ≥ 30 years (OR=2.889, 95% CI: 1.459-5.721) and purple lesions (OR=19.984, 95% CI: 5.704-70.023) were factors related to skin hypertrophy in PWS. Conclusion An age ≥ 30 years and purple lesions seem to be hypertrophy-related factors in PWS. Key words: Port-wine stain; Risk factors; Causality; Hypertrophy