Immune responses and protective efficacy of diet supplementation with selenium nanoparticles against cadmium toxicity in Oreochromis niloticus

Aquaculture ResearchVolume 52, Issue 8 p. 3677-3686 ORIGINAL ARTICLE Immune responses and protective efficacy of diet supplementation with selenium nanoparticles against cadmium toxicity in Oreochromis niloticus Nermeen M. Abu-Elala, Corresponding Author Nermeen M. Abu-Elala [email protected] orcid.org/0000-0002-4785-245X Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt Correspondence Nermeen M. Abu-Elala, Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Email: [email protected]; [email protected]Search for more papers by this authorMohamed Shaalan, Mohamed Shaalan orcid.org/0000-0002-0741-3954 Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSearch for more papers by this authorSara E. Ali, Sara E. Ali Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSearch for more papers by this authorNehal A. Younis, Nehal A. Younis Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSearch for more papers by this author Nermeen M. Abu-Elala, Corresponding Author Nermeen M. Abu-Elala [email protected] orcid.org/0000-0002-4785-245X Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt Correspondence Nermeen M. Abu-Elala, Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Email: [email protected]; [email protected]Search for more papers by this authorMohamed Shaalan, Mohamed Shaalan orcid.org/0000-0002-0741-3954 Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSearch for more papers by this authorSara E. Ali, Sara E. Ali Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSearch for more papers by this authorNehal A. Younis, Nehal A. Younis Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSearch for more papers by this author First published: 13 March 2021 https://doi.org/10.1111/are.15212Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The present study aims to determine the effects of dietary selenium nanoparticles (Se-NPs) on growth, immune response and histopathological alterations induced by sublethal cadmium (Cd) toxicity in Nile tilapia (Oreochromis niloticus). It was carried out through two phases: in the first phase, fish were divided into two groups: a control group fed a basal diet and a treated group fed Se-NP-supplemented diet at 1 mg/kg for four weeks. Growth indices, innate immunological parameters and gene expression of interleukin (IL-1β), tumour necrosis factor (TNF-α), catalase (CAT) and insulin growth factor (IGF-1) were measured. In the second phase, fish were subdivided into four groups: G1, control, G2 was fed a control diet and exposed to Cd (5 mg/L water), G3 was fed Se-NPs-supplemented diet and G4 was fed Se-NPs-supplemented diet and exposed to Cd (5 mg/L water). Tissue samples were collected for histopathological investigation and measuring of malondialdehyde (MDA) and glutathione reduced (GSH) activity 10 days post-Cd exposure. Dietary Se-NPs increased phagocytic and lysozyme activities in the 2nd week, whereas the phagocytic index and growth indices were increased in the 4th week. IGF-1 was upregulated after 2 weeks, and TNF-α, IL-1β and CAT genes upregulated after 4 weeks. Cd caused gill hyperplasia and degenerative changes in visceral organs, elevation in MDA and attenuation in GSH activity. However, in G4 group, the histopathological alterations and antioxidant enzyme were alleviated. Thus, we conclude that dietary Se-NPs improve the growth, immunity and antioxidant power of O. niloticus and alleviate the pathological disorders induced by Cd toxicity. Citing Literature Volume52, Issue8August 2021Pages 3677-3686 RelatedInformation