胰岛素释放
低血糖
胰岛素
阳离子聚合
化学
糖尿病
医学
内科学
内分泌学
高分子化学
1型糖尿病
作者
Jinqiang Wang,Zejun Wang,Guojun Chen,Yanfang Wang,Tianyuan Ci,Hongjun Li,Xiangsheng Liu,Daojia Zhou,Anna R. Kahkoska,Zhuxian Zhou,Huan Meng,John B. Buse,Zhen Gu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-03-08
卷期号:15 (3): 4294-4304
被引量:44
标识
DOI:10.1021/acsnano.0c07291
摘要
Insulin therapy is the central component of treatment for type 1 and advanced type 2 diabetes; however, its narrow therapeutic window is associated with a risk of severe hypoglycemia. A glucose-responsive carrier that demonstrates consistent and slow basal insulin release under a normoglycemic condition and accelerated insulin release in response to hyperglycemia in real-time could offer effective blood glucose regulation with reduced risk of hypoglycemia. Here, we describe a poly(l-lysine)-derived biodegradable glucose-responsive cationic polymer for constructing polymer–insulin complexes for glucose-stimulated insulin delivery. The effects of the modification degree of arylboronic acid in the synthesized cationic polymer and polymer-to-insulin ratio on the glucose-dependent equilibrated free insulin level and the associated insulin release kinetics have been studied. In addition, the blood glucose regulation ability of these complexes and the associated glucose challenge-triggered insulin release are evaluated in type 1 diabetic mice.
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