结直肠癌
癌症研究
下调和上调
转移
烯醇化酶
糖酵解
癌症
生物
基因
酶
生物化学
遗传学
免疫学
免疫组织化学
作者
Jiayi Hou,Jing Cao,Lijuan Gao,Fupeng Zhang,Jing Shen,Lan Zhou,Jianyun Shi,Yanlin Feng,Zi Yan,Deping Wang,Ji‐Min Cao
标识
DOI:10.1016/j.bbrc.2021.09.027
摘要
Lysine crotonylation (Kcr) is a newly identified protein translational modification and is involved in major biological processes including glycolysis, but its role in colorectal cancer (CRC) is unknown. Here, we found that the Kcr of α enolase (ENO1) was significantly elevated in human CRC tissues compared with the paratumoral tissues. CREB-binding protein (CBP) functioned as a crotonyltranferase of ENO1, and SIRT2 was involved in the decrotonylation of ENO1. Using quantitative mass spectrometry for crotonylomics analysis, we further found that K420 was the main Kcr site of ENO1 and ENO1 K420 Kcr promoted the growth, migration, and invasion of CRC cells in vitro by enhancing the activity of ENO1 and regulating the expression of tumor-associated genes. Our study reveals an important mechanism by which ENO1 regulates CRC through crotonylation.
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