Cortical brain organoid as a model to study microgravity exposure

Artificial OrgansVolume 47, Issue 1 p. 5-7 EDITORIAL Cortical brain organoid as a model to study microgravity exposure Luisa Coelho, Luisa Coelho Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USASearch for more papers by this authorAlysson R. Muotri, Corresponding Author Alysson R. Muotri [email protected] Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, Archealization Center (ArchC), La Jolla, California, USA Correspondence Alysson R. Muotri, Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA. Email: [email protected]Search for more papers by this author Luisa Coelho, Luisa Coelho Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USASearch for more papers by this authorAlysson R. Muotri, Corresponding Author Alysson R. Muotri [email protected] Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, Archealization Center (ArchC), La Jolla, California, USA Correspondence Alysson R. Muotri, Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA. Email: [email protected]Search for more papers by this author First published: 31 December 2022 https://doi.org/10.1111/aor.14460Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Roberts DR, Brown TR, Nietert PJ, Eckert MA, Inglesby DC, Bloomberg JJ, et al. Prolonged microgravity affects human brain structure and function. AJNR Am J Neuroradiol. 2019; 40: 1878–85. https://doi.org/10.3174/ajnr.A6249 2Kramer LA, Hasan KM, Stenger MB, Sargsyan A, Laurie SS, Otto C, et al. Intracranial effects of microgravity: a prospective longitudinal MRI study. Radiology. 2020; 295: 640–8. https://doi.org/10.1148/radiol.2020191413 3Barisano G, Sepehrband F, Collins HR, Jillings S, Jeurissen B, Taylor JA, et al. The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts. Proc Natl Acad Sci U S A. 2022; 119(17):e2120439119. https://doi.org/10.1073/pnas.2120439119 4Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster MA. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020; 369(6500):eaaz5626. https://pubmed.ncbi.nlm.nih.gov/32527923/ 5Trujillo CA, Gao R, Negraes PD, Gu J, Buchanan J, Preissl S, et al. Complex oscillatory waves emerging from cortical organoids model early human brain network development. Cell Stem Cell. 2019; 25(4): 558–69. 6Acharya A, Nemade H, Papadopoulos S, Hescheler J, Neumaier F, Schneider T, et al. Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes. iScience. 2022; 25:104577. https://www.sciencedirect.com/science/article/pii/S2589004222008495 7Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, et al. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nature Commun. 2015; 6:8896. https://www.nature.com/articles/ncomms9896 8Muguruma K, Nishiyama A, Kawakami H, Hashimoto K, Sasai Y. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Rep. 2015; 10(4): 537–50. https://pubmed.ncbi.nlm.nih.gov/25640179/ 9Zhao X, Xu Z, Xiao L, Shi T, Xiao H, Wang Y, et al. Review on the vascularization of organoids and organoids-on-a-chip. Front Bioeng Biotechnol. 2021; 9:637048. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072266/ Volume47, Issue1January 2023Pages 5-7 ReferencesRelatedInformation