Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis

Anti-cancer drugs inhibiting platelet-derived growth factor (PDGF) can either promote or inhibit tumour growth and metastasis. Here, Hosaka et al. ascribe this dual effect of anti-PDGF drugs to the production of the angiogenic ligand PDGF-BB by tumours, which is shown to regulate PDGFR-β signalling in pericytes.