Study on the Cross-coupling of Aryl bromides with 2-Amino Acetaldehyde Diethyl Acetal under the Pd Catalyst

A facile method for the preparation of a broad range of N-(2,2-diethoxyethyl)anilines have been developed from the corresponding aryl bromides and 2-amino acetaldehyde diethyl acetal via modified Buchwald-Hartwig reaction.Pd catalyst in situ generated by Pd2(dba)3/XantPhos was found to be efficient in this C-N cross-coupling reaction.Under the optimal reaction conditions,both electron-deficient and electron-rich aryl bromides could smoothly convert to their corresponding N-(2,2-diethoxyethyl)anilines with highly selectivity and the isolated yields were 73%~96%.This new developed method was facile,efficient and easy to operate.