细胞凋亡
血小板
细胞生物学
免疫学
血小板活化
程序性细胞死亡
化学
受体
生物
生物化学
出处
期刊:Blood Reviews
[Elsevier]
日期:2012-03-01
卷期号:26 (2): 51-63
被引量:171
标识
DOI:10.1016/j.blre.2011.10.002
摘要
For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic pathways of apoptosis in nucleated cells and in platelets, platelet apoptosis induced by multiple chemical stimuli and shear stresses, markers of platelet apoptosis, mitochodrial control of platelet apoptosis, and apoptosis mediated by platelet surface receptors PAR-1, GPIIbIIIa and GPIbα. In addition, this review presents data on platelet apoptosis provoked by aging of platelets in vitro during platelet storage, platelet apoptosis in pathological settings in humans and animal models, and inhibition of platelet apoptosis by cyclosporin A, intravenous immunoglobulin and GPIIbIIIa antagonist drugs.
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