Bisphosphonates in Bone Disease: From the Laboratory to the Patient

Bone and Mineral Metabolism: Bone Physiology: Morphology. Composition of bone. Modeling and remodeling. Calcium homeostasis. Bone as an organ. Assessment of bone turnover. Bisphosphonates-Preclinical: Background to the pharmacological development: Chemistry. Actions. Physicochemical effects. Biological effects. Inhibition of bone resorption. Inhibition of mineralization. Pharmocokinetics: Intestinal absorption. Distribution. Renal clearance. Other modes of application. Animal toxicology: Acute toxicology. Nonacute toxicology. Bisphosphonates-clinical: Introduction. Paget's Disease: Definition. Epidemiology. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates. Osteolytic tumor-induced bone disease: Definition. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates. Non-tumor induced hypercalcemia: Definition. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates. Osteoporosis: Definition. Epidemiology. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates. Heterotopic calcification and ossification: Definition. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates. Other diseases: Adverse events: Bisphosphonates in general. Individual bisphosphonates. Contraindications. Future prospects. Commercially available bisphosphonates: Index.