肝细胞生长因子
肝细胞癌
C-Met公司
癌症研究
转移
血管生成
上皮-间质转换
生物标志物
医学
癌症
细胞凋亡
细胞生长
信号转导
肿瘤科
生物
内科学
受体
细胞生物学
遗传学
生物化学
作者
Haiyu Wang,Benchen Rao,Jiamin Lou,Jianhao Li,Zhenguo Liu,Ang Li,Guangying Cui,Zhigang Ren,Zujiang Yu
标识
DOI:10.3389/fcell.2020.00055
摘要
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity receptor, mesenchymal epithelial transition factor (c-Met), are closely related to the onset, progression and metastasis of multiple tumors. The HGF/c-Met axis is involved in cell proliferation, movement, differentiation, invasion, angiogenesis and apoptosis by activating multiple downstream signaling pathways. In this review, we focus on the function of the HGF/c-Met axis in HCC. The HGF/c-Met axis promotes the onset, proliferation, invasion and metastasis of HCC. Moreover, it can serve as a biomarker for diagnosis and prognosis, as well as a therapeutic target for HCC. In addition, it is closely related to drug resistance during HCC treatment.
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