自愈水凝胶
材料科学
胶粘剂
伤口敷料
极限抗拉强度
生物相容性
伤口愈合
纳米纤维
聚合物
细菌纤维素
复合材料
生物医学工程
化学工程
高分子化学
纤维素
外科
医学
图层(电子)
冶金
工程类
作者
Zifeng Yang,Rongkang Huang,Bingna Zheng,Wentai Guo,Chuangkun Li,Wenyi He,Yingqi Wei,Yang Du,Huaiming Wang,Dingcai Wu
标识
DOI:10.1002/advs.202003627
摘要
Abstract Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.
科研通智能强力驱动
Strongly Powered by AbleSci AI