晶体工程
活性成分
生化工程
范围(计算机科学)
班级(哲学)
超分子化学
制药工业
纳米技术
计算机科学
风险分析(工程)
药品
化学
管理科学
业务
材料科学
有机化学
工程类
晶体结构
人工智能
医学
程序设计语言
药理学
作者
Sunil SeethaLekshmi,Tejender S. Thakur,Sunil Varughese
标识
DOI:10.1016/j.jphotochemrev.2021.100455
摘要
Cocrystallization has evolved as an attractive prospect to broaden the chemical landscape of a drug entity, expand its therapeutic scope, and address physicochemical deficiencies of an active pharmaceutical ingredient (API). The non-covalent approaches to address the solubility and bioavailability of BCS Class-II and Class-IV drugs is an archetypal example and is a prolific topic. The present review highlights various supramolecular methods employed in addressing the photoinstability in drugs, emphasizing crystal engineering approaches. Because a greater proportion of the drugs are formulated in the solid-state, the structural factors—crystal packing, intermolecular interactions, packing density—remain a critical determinant in the observed extent of stability. Comprehending and amending these structural determinants using crystal engineering concepts proposes to address the photoinstability in drugs. Also, we highlight the pros and cons of the different adopted strategies in terms of formulation and the underlying challenges and put in prospect. The review provides a correlative assessment of the structure-property relations that could further augment the foundations of factual knowledge in drug stability.
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