细菌
合成生物学
纳米技术
生物技术
材料科学
生物
生化工程
生物信息学
工程类
遗传学
作者
Zhaoting Li,Yixin Wang,Jun Liu,Piper A. Rawding,Jiyoon Bu,Seungpyo Hong,Quanyin Hu
标识
DOI:10.1002/adma.202102580
摘要
Abstract Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria‐based delivery systems have drawn wide interest in the diagnosis and treatment of various diseases, including cancer, infectious diseases, kidney failure, and hyperammonemia. Notably, at the interface of chemical biotechnology and bacteria, many research opportunities have been initiated, opening a promising frontier in biomedical application. Herein, the current synergy of chemical biotechnology and bacteria, the design principles for bacteria‐based delivery systems, the microbial modulation, and the clinical translation are reviewed, with a special focus on the emerging advances in diagnosis and therapy.
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