结合
紫杉醇
连接器
化学
药物输送
药品
氟尿苷
抗药性
核酸
毒品携带者
癌症
药理学
生物化学
医学
氟尿嘧啶
生物
有机化学
内科学
计算机科学
操作系统
数学分析
微生物学
数学
作者
Lijuan Zhu,Yuanyuan Guo,Qiuhui Qian,Deyue Yan,Yuehua Li,Xinyuan Zhu,Chuan Zhang
标识
DOI:10.1002/anie.202006895
摘要
Abstract Combinatorial antitumor therapies using different combinations of drugs and genes are emerging as promising ways to overcome drug resistance, which is a major cause for the failure of cancer treatment. However, dramatic pharmacokinetic differences of drugs greatly impede their combined use in cancer therapy, raising the demand for drug delivery systems (DDSs) for tumor treatment. By employing fluorescent dithiomaleimide (DTM) as a linker, we conjugate two paclitaxel (PTX) molecules with a floxuridine (FdU)‐integrated antisense oligonucleotide (termed chemogene) to form a drug–chemogene conjugate. This PTX–chemogene conjugate can self‐assemble into a spherical nucleic acid (SNA)‐like micellular nanoparticle as a carrier‐free DDS, which knocks down the expression of P‐glycoprotein and subsequently releases FdU and PTX to exert a synergistic antitumor effect and greatly inhibit tumor growth.
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