基因敲除
细胞生物学
转录因子
癌变
竞争性内源性RNA
转移
细胞迁移
细胞生长
癌症
信号转导
下调和上调
基因沉默
小RNA
上皮-间质转换
作者
Maonan Wang,Manli Dai,Dan Wang,Ting Tang,Fang Xiong,Bo Xiang,Ming Zhou,Xiaoling Li,Yong Li,Wei Xiong,Guiyuan Li,Zhaoyang Zeng,Can Guo
标识
DOI:10.1016/j.canlet.2021.04.025
摘要
Long noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved in several pathological responses. However, many important lncRNAs in breast cancer have not been identified and their expression levels and functions in breast cancer remain unknown. In this study, the lncRNA apoptosis-associated transcript in bladder cancer (AATBC) was found to be significantly highly expressed in breast cancer patients. In vitro and in vivo experiments indicated that AATBC promoted breast cancer metastasis. Further studies revealed that AATBC activated the YAP1/Hippo signaling pathway through the AATBC-YBX1-MST1 axis. This is also an important supplement to the composition of the YAP1/Hippo signaling pathway. The model of “AATBC-YAP1” may bring a new dawn to the treatment of breast cancer.
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