Age and sex dependent association of uric acid and incident hypertension

医学 高尿酸血症 血压 内科学 比例危险模型 尿酸 前瞻性队列研究 痛风 队列 队列研究
作者
Woohyeun Kim,Tae‐Hwa Go,Dong Oh Kang,Jieun Lee,Jah Yeon Choi,Seung‐Young Roh,Jin Oh Na,Cheol Ung Choi,Seung‐Woon Rha,Chang Gyu Park,Hong Seog Seo,Dae Ryong Kang,Jang‐Young Kim,Eung Ju Kim
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier BV]
卷期号:31 (4): 1200-1208 被引量:14
标识
DOI:10.1016/j.numecd.2020.12.015
摘要

Background and aims A previous meta-analysis suggested that the relationship between hyperuricemia and hypertension may be stronger in younger individuals and women. We aimed to investigate the age and sex dependent association of uric acid (UA) and incident hypertension. Methods and results We analyzed data from the Health Examinees Study, a community-based prospective cohort study conducted in Korea from 2004 to 2013. It included 29,088 non-hypertensive subjects aged 40–79 (age, 52.5 ± 7.8 years; men, 31.4%) who had serum UA measurement and participated in the follow-up survey. The risk factors of hypertension were assessed using Cox regression. Over a mean 3.8 years of follow-up, 1388 men (15.2%) and 1942 women (9.7%) were newly diagnosed with hypertension. Upon age- and sex-based stratification, the risk of hypertension was highest in hyperuricemic subjects aged 40–49 years (HR: women, 2.16; men, 1.30). Across the entire cohort, the risk of incident hypertension was higher in groups with higher serum UA levels, and highest in women aged 40–49 years (HR, 1.44; P < 0.001). On multivariable linear regression analysis, the higher the baseline serum UA level, the greater the increase in blood pressure during follow-up, and this effect was strongest in women aged 40–49 years (β = 0.87 and P < 0.01 for systolic blood pressure). Conclusions The relationship between uric acid and incident hypertension tended to be dependent on age and sex. Younger women are at highest risk of UA-related incident hypertension.
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