Niacin-ligated platinum(iv)–ruthenium(ii) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicityin vivo

The chimeric Pt(iv)–Ru(ii) complex was designed to simultaneously release cytotoxic cisplatin and an antimetastatic Ru(ii)–arene compound, thereby producing potent anticancer activity with high drug tolerability in animals.