脂解
化学
胡桃
胡桃科
传统医学
植物
立体化学
生物
脂肪组织
生物化学
医学
作者
Seon Ju Park,Nanyoung Kim,Gayoung Yoo,Sang Nam Kim,Hyun Jung Kwon,Kiwon Jung,Dong Chan Oh,Yun Hee Lee,Seung Hyun Kim
标识
DOI:10.1016/j.phytochem.2017.01.019
摘要
Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts. Among them, 2-(4-formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol exhibited the most potent lipolytic activities.
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