A comprehensive review on the decabromodiphenyl ether (BDE-209)-induced male reproductive toxicity: Evidences from rodent studies

生殖毒性 十溴二苯醚 多溴联苯醚 二苯醚 毒性 溴化阻燃剂 生物 多溴联苯 毒理 生理学 污染物 医学 化学 内科学 生态学 阻燃剂 有机化学
作者
Debarshi Sarkar,Parul Midha,Shashanka Sekhar Shanti,Shio Kumar Singh
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:901: 165938-165938 被引量:3
标识
DOI:10.1016/j.scitotenv.2023.165938
摘要

Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants (BFRs), are employed in various manufactured products to prevent fires, slow down their spread and reduce the resulting damages. Decabromodiphenyl ether (BDE-209), an example of PBDEs, accounts for approximately 82 % of the total production of PBDEs. BDE-209 is a thyroid hormone (TH)-disrupting chemical owing to its structural similarity with TH. Currently, increase in the level of BDE-209 in biological samples has become a major issue because of its widespread use. BDE-209 causes male reproductive toxicity mainly via impairment of steroidogenesis, generation of oxidative stress (OS) and interference with germ cell dynamics. Further, exposure to this chemical can affect metabolic status, sperm concentration, epigenetic regulation of various developmental genes and integrity of blood-testis barrier in murine testis. However, the possible adverse effects of BDE-209 and its mechanism of action on the male reproductive health have not yet been critically evaluated. Hence, the present review article, with the help of available literature, aims to elucidate the reproductive toxicity of BDE-209 in relation to thyroid dysfunction in rodents. Further, several crucial pathways have been also highlighted in order to strengthen our knowledge on BDE-209-induced male reproductive toxicity. Data were extracted from scientific articles available in PubMed, Web of Science, and other databases. A thorough understanding of the risk assessment of BDE-209 exposure and mechanisms of its action is crucial for greater awareness of the potential threat of this BFR to preserve male fertility.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lexa发布了新的文献求助10
刚刚
刚刚
王嘉尔完成签到,获得积分20
1秒前
麻辣香锅应助星下梧桐采纳,获得30
1秒前
2秒前
4秒前
科研公主完成签到,获得积分10
5秒前
5秒前
科目三应助努力毕业、采纳,获得10
6秒前
冷静的胜完成签到,获得积分10
6秒前
薄荷小新完成签到 ,获得积分10
6秒前
wangcy发布了新的文献求助10
7秒前
彩虹雨发布了新的文献求助10
10秒前
10秒前
xin完成签到 ,获得积分10
12秒前
13秒前
端庄煎饼完成签到,获得积分10
13秒前
思无邪完成签到 ,获得积分10
14秒前
15秒前
MingqingFang发布了新的文献求助10
18秒前
19秒前
20秒前
20秒前
20秒前
开朗的觅柔完成签到,获得积分10
21秒前
一一应助科研通管家采纳,获得30
21秒前
科研通AI2S应助科研通管家采纳,获得10
21秒前
完美世界应助科研通管家采纳,获得10
21秒前
科研通AI2S应助科研通管家采纳,获得10
21秒前
伶俐的雁蓉完成签到,获得积分10
21秒前
请叫我鬼才完成签到,获得积分10
25秒前
Dee发布了新的文献求助10
26秒前
王嘉尔发布了新的文献求助10
26秒前
myy发布了新的文献求助10
27秒前
顺心子轩完成签到 ,获得积分10
30秒前
NexusExplorer应助garey采纳,获得10
31秒前
Yiqi完成签到,获得积分10
31秒前
Dee完成签到,获得积分10
32秒前
羽渡尘完成签到,获得积分10
33秒前
Singularity应助饱满绮波采纳,获得10
33秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3155767
求助须知:如何正确求助?哪些是违规求助? 2807008
关于积分的说明 7871598
捐赠科研通 2465380
什么是DOI,文献DOI怎么找? 1312221
科研通“疑难数据库(出版商)”最低求助积分说明 629947
版权声明 601905