医学
中枢神经系统
血脑屏障
炎症
神经科学
糖萼
机制(生物学)
病理生理学
冲程(发动机)
生物信息学
免疫学
病理
生物
内科学
机械工程
哲学
认识论
工程类
作者
Weihao Ye,Shang Xu,Ying Liu,Ziming Ye
出处
期刊:Reviews in The Neurosciences
[De Gruyter]
日期:2024-07-22
卷期号:35 (8): 839-853
标识
DOI:10.1515/revneuro-2024-0039
摘要
Abstract Central nervous system (CNS) diseases, such as stroke, traumatic brain injury, dementia, and demyelinating diseases, are generally characterized by high morbidity and mortality, which impose a heavy economic burden on patients and their caregivers throughout their lives as well as on public health. The occurrence and development of CNS diseases are closely associated with a series of pathophysiological changes including inflammation, blood–brain barrier disruption, and abnormal coagulation. Endothelial glycocalyx (EG) plays a key role in these changes, making it a novel intervention target for CNS diseases. Herein, we review the current understanding of the role of EG in common CNS diseases, from the perspective of individual pathways/cytokines in pathophysiological and systematic processes. Furthermore, we emphasize the recent developments in therapeutic agents targeted toward protection or restoration of EG. Some of these treatments have yielded unexpected pharmacological results, as previously unknown mechanisms underlying the degradation and destruction of EG has been brought to light. Furthermore, the anti-inflammatory, anticoagulative, and antioxidation effects of EG and its protective role exerted via the blood–brain barrier have been recognized.
科研通智能强力驱动
Strongly Powered by AbleSci AI