蓼
机制(生物学)
传统医学
化学
医学
物理
量子力学
作者
Liping Gong,Xianhui Shen,Nana Huang,Kaiyi Wu,Rongrong Li,Ying Liu,Huijie Zhang,Siyi Chen,Rong Sun
出处
期刊:Toxicon
[Elsevier]
日期:2024-07-20
卷期号:248: 108040-108040
被引量:1
标识
DOI:10.1016/j.toxicon.2024.108040
摘要
As a traditional tonic Chinese medicine, Polygonum multiflorum is widely used in clinical practice. However, with the deepening of modern pharmacological research, its drug toxicity, especially hepatotoxicity, has become increasingly prominent. Based on a large number of clinical and experimental evidence, it has been confirmed that Polygonum multiflorum and its main active ingredients such as anthraquinones and diphenylethylene glucoside can cause different degrees of hepatotoxicity. Further studies have shown that the toxicological mechanisms involved in the hepatotoxicity of different extracts and components of Polygonum multiflorum may include oxidative phosphorylation, bile acid excretion, different metabolic pathways, genetic and metabolic factors, immune homeostasis, etc. By sorting out and summarizing the literature related to hepatotoxicity of Polygonum multiflorum in recent years, this paper discussed the hepatotoxicity mechanism of Polygonum multiflorum and its main components and some contradictions in related reports.
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