Anatomy and Physiology of the Stomach

In this article, key concepts in gastric anatomy and physiology are reviewed. Attention is given to historical development of concepts of acid secretion, to the role of stomach in digestion, and to the mechanisms that protect gastric mucosa from acid and hostile luminal conditions. Evolving ideas that may influence understand-ing of the physiologic consequences of emerging therapeutics, and procedures that target anatomy or function of the stomach are also reviewed.