Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity

咖啡因 背景(考古学) 医学 糖尿病 危险系数 内科学 生理学 内分泌学 环境卫生 置信区间 生物 古生物学
作者
Xujia Lu,Xiaohong Zhu,Guochen Li,Luying Wu,Liping Shao,Yulong Fan,Chen‐Wei Pan,Ying Wu,Yan Borné,Chaofu Ke
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
被引量:1
标识
DOI:10.1210/clinem/dgae552
摘要

Abstract Context Cardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual cardiometabolic diseases; however, their associations with CM and related biological markers are unknown. Methods This prospective study involved 172 315 (for caffeine analysis) and 188 091 (tea and coffee analysis) participants free of any cardiometabolic diseases at baseline from the UK Biobank; 168 metabolites were measured among 88 204 and 96 393 participants. CM was defined as the coexistence of at least 2 of the following conditions: type 2 diabetes, coronary heart disease, and stroke. Results Nonlinear inverse associations of coffee, tea, and caffeine intake with the risk of new-onset CM were observed. Compared with nonconsumers or consumers of less than 100 mg caffeine per day, consumers of moderate amount of coffee (3 drinks/d) or caffeine (200-300 mg/d) had the lowest risk for new-onset CM, with respective hazard ratios (95% CIs) of 0.519 (0.417-0.647) and 0.593 (0.499-0.704). Multistate models revealed that moderate coffee or caffeine intake was inversely associated with risks of almost all developmental stages of CM, including transitions from a disease-free state to single cardiometabolic diseases and subsequently to CM. A total of 80 to 97 metabolites, such as lipid components within very low-density lipoprotein, histidine, and glycoprotein acetyls, were identified to be associated with both coffee, tea, or caffeine intake and incident CM. Conclusion Habitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM and could play important roles in almost all transition phases of CM development. Future studies are warranted to validate the implicated metabolic biomarkers underlying the relation between coffee, tea, and caffeine intake and CM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
善良的人发布了新的文献求助10
1秒前
怕黑的凝旋完成签到,获得积分10
1秒前
现代书雪完成签到,获得积分20
1秒前
彭于晏应助paltahun采纳,获得10
2秒前
斯文败类应助blawxx采纳,获得10
2秒前
bm发布了新的文献求助10
3秒前
3秒前
果冻橙发布了新的文献求助10
3秒前
xixi发布了新的文献求助10
3秒前
华仔应助Zenobia采纳,获得10
4秒前
5秒前
5秒前
学呀完成签到,获得积分10
5秒前
幸福胡萝卜完成签到,获得积分10
6秒前
健忘鞋垫完成签到,获得积分10
7秒前
AZURE完成签到,获得积分10
8秒前
lbj发布了新的文献求助10
8秒前
量子星尘发布了新的文献求助10
8秒前
白了个白发布了新的文献求助20
8秒前
完美世界应助嘟嘟采纳,获得10
9秒前
bobochi发布了新的文献求助30
9秒前
bm完成签到,获得积分10
10秒前
10秒前
羽羽完成签到 ,获得积分10
11秒前
xiaoxia完成签到,获得积分10
12秒前
14秒前
顾矜应助inferyes采纳,获得10
15秒前
oleskarabach发布了新的文献求助10
15秒前
听曲散步完成签到,获得积分10
16秒前
qq发布了新的文献求助10
17秒前
paltahun发布了新的文献求助10
17秒前
17秒前
科研民工李完成签到,获得积分10
17秒前
17秒前
娜娜完成签到 ,获得积分10
18秒前
L2发布了新的文献求助30
19秒前
花花猪1989发布了新的文献求助20
20秒前
李思发布了新的文献求助10
22秒前
liyq完成签到,获得积分10
23秒前
暮光微凉发布了新的文献求助10
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969940
求助须知:如何正确求助?哪些是违规求助? 3514642
关于积分的说明 11175298
捐赠科研通 3249947
什么是DOI,文献DOI怎么找? 1795178
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891