肝保护
肠道菌群
肝损伤
毛螺菌科
益生元
封堵器
氧化应激
抗氧化剂
杜仲
多糖
谷胱甘肽
酒精性肝病
药理学
化学
生物
生物化学
医学
内科学
紧密连接
病理
替代医学
中医药
酶
肝硬化
厚壁菌
基因
16S核糖体RNA
作者
Yingzhi Li,Huimei Wang,Xueping Leng,Jiaming Gao,Chang Li,Mingyong Xie
出处
期刊:Foods
[MDPI AG]
日期:2024-04-02
卷期号:13 (7): 1089-1089
被引量:3
标识
DOI:10.3390/foods13071089
摘要
The interplay among gut microbiota, intestines, and liver is crucial in preventing acute alcoholic liver injury. In this study, the hepatoprotective potential of polysaccharides from Eucommia ulmoides Oliv. leaves (EULP) on acute alcoholic liver injury in Kunming male mice was investigated. The structural features suggested that the EULP appeared as a heterogeneous mixture of polysaccharides with a molecular weight of 186132 Da. A 14-day pretreatment of EULP ameliorated acute alcoholic-induced hepatic inflam mation (TNF-α, IL-6, and IL-10), oxidative stress (GSH, SOD, and T-AOC), and liver damage (ALT and AST) via enhancing intestinal barrier (Occludin, Claudin 1, and ZO-1) and modulating microbiome, which subsequently inhibiting endotoxemia and balancing the homeostasis of the gut–liver axis. EULP restored the composition of intestinal flora with an increase in the relative abundance of Lactobacillaceae and a decrease in Lachnospiraceae and Verrucomicrobiaceae. Notably, prolonged EULP pretreatment (14 days) but no single gavage of EULP achieved excellent hepatoprotection. These findings endorsed the potential of EULP as a functional food for mitigating acute alcoholic-induce d liver damage, attributed to its anti-inflammatory, antioxidant, and prebiotic properties facilitated by the microbiota–gut–liver axis.
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