Comparative study of antioxidant and antimicrobial activity of berberine-derived Schiff bases, nitro-berberine and amino-berberine

小檗碱 化学 抗菌剂 DPPH 抗氧化剂 生物碱 异喹啉 有机化学
作者
Soheila Alipour Noghabi,Pouya Ghamari Kargar,Ghodsieh Bagherzade,Hamid Beyzaei
出处
期刊:Heliyon [Elsevier]
卷期号:9 (12): e22783-e22783 被引量:5
标识
DOI:10.1016/j.heliyon.2023.e22783
摘要

In recent years, the scientific community has focused on traditional natural products and their potential therapeutic benefits. Berberine is a plant-derived isoquinoline alkaloid with a variety of biological properties and identified as a promising pharmacophore for discovering new therapeutic agents against various diseases. However, unfavorable pharmacokinetic properties of berberine have limited its clinical application so much that researchers pursue its structure modification to overcome this problem. This study focuses on the synthesis of new berberine derivatives to improve its antioxidant and antimicrobial potentials, which were characterized using CHNO and NMR instruments. Berberine extracted from barberry root was nitrated, reduced to amine and condensed with benzaldehyde derivatives to produce berberine-based Schiff bases. The H atom donating ability of all compounds was measured against DPPH free radicals, with IC50 values ranging from 18.28 to 108.20 μg ml-1. All berberine-based Schiff bases exhibited stronger antioxidant activity than nitro-berberine and amino-berberine. Only Schiff base derived from 4-hydroxybenzaldehyde showed slightly better antioxidant effects than original berberine. The inhibitory effects of the synthesized compounds were evaluated against important pathogenic fungal and bacterial strains using disk diffusion assays, with inhibition zone diameters ranging from 8.36 to 25.48 μg ml-1. Berberine itself only affected Candida albicans fungus. Nitrated berberine was effective against all microorganisms except Gram-negative Acinetobacter baumannii. The results suggest that structural modifications and functionalization can enhance the antimicrobial and antioxidant properties of berberine.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
3秒前
ayayaya完成签到 ,获得积分10
5秒前
babayega完成签到,获得积分20
7秒前
田様应助Tantantan采纳,获得10
7秒前
8秒前
mjn404发布了新的文献求助10
10秒前
所所应助feiten采纳,获得10
11秒前
12秒前
wanci应助直率亦玉采纳,获得10
12秒前
乐乐发布了新的文献求助30
13秒前
13秒前
14秒前
15秒前
北三十完成签到,获得积分10
16秒前
starofjlu应助啤酒白菜采纳,获得30
18秒前
babayega发布了新的文献求助10
19秒前
19秒前
纯真电源关注了科研通微信公众号
20秒前
Aurora完成签到 ,获得积分10
20秒前
诸苑博发布了新的文献求助10
20秒前
24秒前
Hello应助简单澜采纳,获得10
24秒前
26秒前
诚心凌文完成签到,获得积分10
28秒前
28秒前
遇鲸还潮完成签到,获得积分10
31秒前
31秒前
maaicui发布了新的文献求助10
31秒前
34秒前
34秒前
35秒前
曦子曦子完成签到,获得积分10
36秒前
life发布了新的文献求助10
37秒前
纯真电源发布了新的文献求助10
37秒前
脑洞疼应助繁星采纳,获得10
38秒前
38秒前
聪明迎海发布了新的文献求助10
39秒前
41秒前
sirius完成签到,获得积分10
42秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 600
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3151938
求助须知:如何正确求助?哪些是违规求助? 2803228
关于积分的说明 7852661
捐赠科研通 2460630
什么是DOI,文献DOI怎么找? 1309955
科研通“疑难数据库(出版商)”最低求助积分说明 629087
版权声明 601760