Catalytic Asymmetric 1,4‐Hydrocarbonation of 1,3‐Enynes via Photoredox/Cobalt/Chromium Triple Catalysis

A synergistic photoredox/cobalt/chromium triple catalysis system for regioselective, enantioselective, and diastereoselective 1,4‐hydrocarbonation of readily available 1,3‐enyne precursors was explored, providing a modular synthetic platform for various trisubstituted axially chiral allenes bearing an extra central chirality. The protocol features a broad substrate scope, good functional group tolerance, excellent selectivity, and mild reaction conditions. Furthermore, a possible reaction mechanism is proposed based on numerous control experiments and density functional theory calculations.