医学
四分位间距
伤口愈合
伤口闭合
牙科
外科
随机对照试验
作者
Stefan Bienz,Naida Gadzo,Anina N. Zuercher,Daniel B. Wiedemeier,Ronald E. Jung,Daniel S. Thoma
摘要
Abstract Aim To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen‐based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology. Materials and Methods Twenty participants were enrolled in this experimental study, in whom four palatal defects were created. The defects (6 mm diameter, 3 mm depth) were randomly assigned to one of four treatment modalities: C (control), MG (Mucograft®), MD (mucoderm®) and FG (Fibro‐Gide®). Photographs were taken, and pain assessment was performed before and after treatment and at 5, 7, 9, 12, 14 and 16 days after surgery. All participants wore a palatal splint for a duration of 16 days. Results All groups achieved complete wound closure at 14 days. The percentage of the remaining open wound on day 7 amounted to 49.3% (C; interquartile range [IQR]: 22.6), 70.1% (FG; IQR: 20.7), 56.8% (MD; IQR: 26.3) and 62.2% (MG; IQR: 34.4). Statistically significant differences were found between FG and C ( p =.01) and between MD and FG ( p =.04). None of the participants rated pain higher than 4 out of 10 during the entire study period. Conclusions Collagen‐based wound dressings provide coverage of open defects, albeit without acceleration of wound closure or reduction of pain. FG (which is not intended for open oral wounds) showed slower wound closure compared to C and MD.
科研通智能强力驱动
Strongly Powered by AbleSci AI