质粒
毒力
肺炎克雷伯菌
微生物学
生物
克雷伯菌
拉伤
基因
肠杆菌科
遗传学
大肠杆菌
解剖
作者
Xuemei Yang,Edward Wai‐Chi Chan,Rong Zhang,Sheng Chen
出处
期刊:Nature microbiology
日期:2019-09-30
卷期号:4 (12): 2039-2043
被引量:106
标识
DOI:10.1038/s41564-019-0566-7
摘要
A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.
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