An Expedient Route to Optically Pure 1-Butyne-3,4-diol from 2,5-Dihydrofuran

Optically pure 1-butyne-3,4-diol has been obtained expediently in a satisfactory overall yield from 2,5-dihydrofuran on sequential epoxidation, nucleophilic cleavage, lipase-mediated resolution, and base-induced double elimination.