抗坏血酸
差示扫描量热法
聚乙烯醇
核化学
材料科学
扫描电子显微镜
傅里叶变换红外光谱
静电纺丝
化学
化学工程
聚合物
有机化学
复合材料
物理
食品科学
工程类
热力学
作者
Muhammad Sohail Arshad,Muhammad Hamza,Saman Zafar,Sadia Jafar Rana,Haji Muhammad Shoaib Khan,Tahir Ali Chohan,Khizar Abbas,Tanveer Ahmad,Zeeshan Ahmad
标识
DOI:10.1016/j.jddst.2023.105104
摘要
This study aims to fabricate ascorbic acid incorporated polyvinyl pyrrolidone (PVP) and polyvinyl alcohol (PVA)-based micro-material (labelled as AM) by using electrospinning technique. The micro-material was loaded into Carbopol 934, collagen, and aloe vera-based gel to develop a suitable topical dosage form (labelled as AMG). Morphological, thermal, and phase analysis of electrospun material AM was carried out by scanning electron microscope (SEM), differential scanning calorimeter (DSC) and X-ray diffractometer (XRD). Fourier transform infrared spectroscopy (FTIR) and in-silico analysis were performed to study the interactions between ascorbic acid, PVP and PVA. The prepared gel formulation AMG was evaluated for stability, in-vitro drug release and in-vivo cosmeceutical evaluation. Morphological analysis revealed the presence of micron-scaled fibres and beads (diameter 0.58 ± 0.19 μm and 1.33 ± 0.38 μm, respectively) in the formulation AM. Ascorbic acid was incorporated within the polymeric micro-material in an amorphous state. Ascorbic acid interacted with PVP and PVA by forming hydrogen bonds. Formulation AMG remained stable during the study period (3 months) and showed antioxidant activity of >90% possibly due to the encapsulation of drug within the polymeric matrix. The prepared formulation AMG provided relatively rapid and higher release of ascorbic acid i.e., 77.9 ± 2.5% (gradient 12.69) within 6 h possibly due to the amorphization of drug and avoidance of degradation, respectively. In comparison, pure ascorbic acid loaded gel (labelled as AG) released only 43.7 ± 3.1% (gradient 6.67) drug within 6 h. During in-vivo study in human subjects, a significant decrease was observed in the melanin (∼10 times, gradient 3.57) and erythema (∼9 times, gradient 3.09) levels of skin as compared to the control level (before treatment). Moreover, the skin elasticity increased by 6 times (gradient 2.77) following treatment with formulation AMG as compared to the control value. Thus, it was concluded that the prepared electrospun polymeric micro-material loaded gel system can be used as a carrier for topical delivery of ascorbic acid.
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